The Power of Systemic Enzymes
Most enzyme supplements are designed to support digestion, but systemic enzymes serve a very different purpose.
Instead of working on food in the gut, systemic enzymes are taken on an empty stomach so they can be absorbed into the bloodstream. From there, they support processes throughout the body, including circulation, recovery, and immune function.
Your body relies on both digestive and systemic enzymes. Digestive enzymes help break down proteins, fats, and carbohydrates during meals. Systemic enzymes, on the other hand, are used between meals to support whole-body balance beyond digestion.
If your goal is digestive support, a traditional enzyme formula may be helpful. But if you're looking to support circulation, joint and muscle comfort, and recovery, a systemic enzyme complex like Nutrizyme is designed for that purpose.
Too Much of a Good Thing
Fibrin is a protein that helps your blood clot, which is an essential process for healing wounds. However, imbalanced fibrin levels may affect normal circulation.
Supporting healthy fibrin balance may provide several benefits:
- Supports healthy blood viscosity for proper circulation
- Promotes joint and muscle comfort after physical activity
- Encourages recovery, making it easier to bounce back after injuries or trauma
How can you support healthy fibrin balance in the body? Systemic enzymes may help support normal protein metabolism and circulation.
Nutrizyme provides a blend of proteolytic (protein-digesting) enzymes commonly studied for their role in supporting recovery and circulation, including pancreatin, papain, bromelain, trypsin, and chymotrypsin, designed to support the breakdown of proteins in the body. This advanced formula also features targeted botanicals, including mushrooms and herbs, to enhance immune response.
Why This Enzyme Blend Matters
Not all enzyme supplements are created equal. Nutrizyme combines multiple proteolytic enzymes to provide broad-spectrum support:
- Bromelain – Studied for its role in supporting post-exercise recovery and inflammation balance
- Papain – Helps break down proteins and supports tissue health
- Pancreatin – A comprehensive enzyme complex that supports protein, fat, and carbohydrate metabolism
- Trypsin & Chymotrypsin – Proteolytic enzymes that support normal inflammatory response and tissue repair
By combining multiple enzymes, Nutrizyme is designed to support whole-body processes rather than targeting a single function.
The Science Behind the Formula
Supports Healthy Circulation
Blood needs the proper viscosity to move efficiently through your blood vessels and deliver oxygen and nutrients to your cells. By supporting healthy fibrin balance, Nutrizyme helps maintain normal blood flow.
The bioflavonoid rutin has also been studied for its role in supporting vascular health and circulation.
Helps Alleviate Minor Joint and Muscle Discomfort
Pushing your limits feels great until the soreness sets in. Nutrizyme supports a balanced inflammatory response following exercise, helping maintain comfort and mobility.
Supports Natural Healing
Your body is equipped with a natural ability to recover from physical stress, but sometimes it can use a little nudge. Nutrizyme promotes a balanced physiological response, which may support recovery and normal tissue repair — so you can get back to feeling your best.
Enhances Immune Response
Excess proteins in tissues may interfere with normal immune activity. Nutrizyme is designed to support the breakdown of these proteins, helping maintain healthy immune function. Shiitake mushroom powder and Venus fly trap—a distinctive botanical used in specialized wellness formulations—provide additional immune-supporting compounds.
Provides Antioxidant Protection Against Oxidative Stress
Physical activity and daily stressors can increase oxidative stress—an imbalance between free radicals and your body’s defenses. Nutrizyme delivers plant-based antioxidants that help support cellular health and protect against oxidative stress.
Maximum Absorption
Your body only uses what it can absorb. Nutrizyme features an enteric coating, which helps protect enzymes from stomach acid so they can pass through the stomach intact and be released in the small intestine for optimal absorption.
This delivery method is especially important for systemic enzymes, which are intended to reach the bloodstream rather than be used for digestion.

Systemic vs Digestive Enzymes: What’s the Difference?
While both types of enzymes play important roles, the key difference comes down to how and when they’re used:
- Digestive enzymes are taken with meals to help break down food in the digestive tract
- Systemic enzymes are taken away from food and are intended to be absorbed into the bloodstream
Because of this difference, systemic enzymes are commonly used to support circulation, recovery, and overall physiological balance, rather than digestion.
Who Should Consider Systemic Enzymes?
Systemic enzymes may be a helpful addition for individuals who:
- Live an active lifestyle and want to support recovery
- Are looking to support healthy circulation
- Want whole-body support beyond digestion
- Are focused on maintaining long-term wellness and mobility
If you're looking for a systemic enzyme formula designed for circulation, recovery, and whole-body support, Nutrizyme combines proteolytic enzymes, immune-supporting compounds, and targeted delivery for optimal absorption.
References:
- Vilar, Rui, et al. "Fibrin(ogen) in Human Disease: Both Friend and Foe." Haematologica, vol. 105, no. 2, Feb. 2020, https://doi.org/10.3324/haematol.2019.236901.
- Bakhshi, G. D., et al. "Systemic Enzyme Therapy in Chronic Venous Disease: A Review." International Journal of Research in Medical Sciences, vol. 9, no. 9, 2021, pp. 2869–2876, https://doi.org/10.18203/2320-6012.ijrms20213435.
- Bazyar, Hadi, et al. "The Effects of Rutin Supplement on Blood Pressure Markers, Some Serum Antioxidant Enzymes, and Quality of Life in Patients with Type 2 Diabetes Mellitus Compared with Placebo." Frontiers in Nutrition, vol. 10, Aug. 3, 2023, article 1214420, https://doi.org/10.3389/fnut.2023.1214420.
- Chiou, George C. Y., and Xin-Rong Xu. "Effects of Some Natural Flavonoids on Retinal Function Recovery after Ischemic Insult in the Rat." Journal of Ocular Pharmacology and Therapeutics, vol. 20, no. 2, Apr. 2004, pp. 107–113, https://doi.org/10.1089/108076804773710777.
- Marzin, Tobias, et al. "Effects of a Systemic Enzyme Therapy in Healthy Active Adults after Exhaustive Eccentric Exercise: A Randomised, Two-Stage, Double-Blinded, Placebo-Controlled Trial." BMJ Open Sport & Exercise Medicine, vol. 2, no. 1, Mar. 12, 2017, article e000191, https://doi.org/10.1136/bmjsem-2016-000191.
- Brien, Sarah, et al. “Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.” Evid Based Complement Alternat, vol. 1, no. 3, Oct. 6, 2004, doi: 10.1093/ecam/neh035
- Akhtar, Naseer M., et al. "Oral Enzyme Combination versus Diclofenac in the Treatment of Osteoarthritis of the Knee: A Double-Blind Prospective Randomized Study." Clinical Rheumatology, vol. 23, no. 5, Oct. 2004, pp. 410–415. Springer, https://doi.org/10.1007/s10067-004-0902-y.